Abstract Background Burgeoning evidence highlights seminal roles for microglia in the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS).The receptor for advanced glycation end products (RAGE) binds ligands relevant to ALS that accumulate in the diseased spinal cord and RAGE has been previously implicated in th
The Lysosome Origin of Biosilica Machinery in the Demospongiae Model Petrosia ficiformis (Poiret, 1789)
The silicification mechanism in sponges VIRUX is a biologically controlled process where the complex and amazing shape of spicules is the result of the hierarchical assembly of silicon particles to form a composite structure with organic compounds, mainly constituted by proteins.In this work, using an integrated approach of transcriptomic and prote
Possibility of the Use of Different Types of Materials in Passive Ventilation Systems of Munitions
The paper presents different types of insensitive munition used in military equipment, especially in western RASPBERRY ZINGER countries.Tests of this munition, their parameters, e.g.fast and slow heating, bullet, fragment and shaped charge jet impact and sympathetic reaction are described.The characteristics of shape-memory materials like alloys an
Heroin Inhibits HIV-Restriction miRNAs and Enhances HIV Infection of Macrophages
Although opioids have been extensively studied for their impact on the immune system, limited information is available about the specific actions of opioids on intracellular antiviral innate immunity against HIV infection.Thus, we investigated whether heroin, one of the most abused drugs, inhibits the expression of intracellular HIV restriction mic